吲达帕胺与苄氟噻嗪：原发性高血压治疗的比较
Indapamide and bendrofluazide: a comparison in the management of essential hypertension.
作者信息
Bing R F, Russell G I, Swales J D, Thurston H
出版信息
Br J Clin Pharmacol. 1981 Dec;12(6):883-6. doi: 10.1111/j.1365-2125.1981.tb01325.x.
Abstract
1 To compare the efficacy of indapamide with that of bendrofluazide a randomised trial was carried out in twenty patients with essential hypertension. 2 Indapamide (2.5 mg a day) and bendrofluazide (5 mg a day) produced a significant but equivalent fall in blood pressure. 3 Both drugs caused a reduction in body weight and serum potassium with a rise in plasma renin activity but there were no other major side effects. 4 In twelve patients treated with a combination of indapamide and bendrofluazide there was no additional fall in mean blood pressure or serum potassium compared to treatment with bendrofluazide or indapamide alone.
摘要
为比较吲达帕胺与苄氟噻嗪的疗效，对20例原发性高血压患者进行了一项随机试验。
吲达帕胺（每日2.5毫克）和苄氟噻嗪（每日5毫克）均使血压显著下降，但降幅相当。
两种药物均导致体重和血清钾降低，同时血浆肾素活性升高，但无其他严重副作用。
与单独使用苄氟噻嗪或吲达帕胺相比，12例接受吲达帕胺与苄氟噻嗪联合治疗的患者，其平均血压或血清钾并无进一步下降。
相似文献
1
Indapamide and bendrofluazide: a comparison in the management of essential hypertension.吲达帕胺与苄氟噻嗪：原发性高血压治疗的比较
Br J Clin Pharmacol. 1981 Dec;12(6):883-6. doi: 10.1111/j.1365-2125.1981.tb01325.x.
2
A comparative study of the efficacy of indapamide and bendrofluazide given in combination with atenolol.吲达帕胺与苄氟噻嗪联合阿替洛尔疗效的比较研究。
Postgrad Med J. 1981;57 Suppl 2:51-2.
3
Verapamil and bendrofluazide in the treatment of hypertension: a controlled study of effectiveness alone and in combination.维拉帕米和苄氟噻嗪治疗高血压：单独及联合用药疗效的对照研究
Eur J Clin Pharmacol. 1988;34(3):249-53. doi: 10.1007/BF00540951.
4
A comparison of the acute effects of cicletanine and bendrofluazide on urinary electrolytes and plasma potassium in essential hypertension.环戊噻嗪和苄氟噻嗪对原发性高血压患者尿电解质及血浆钾急性影响的比较
Eur J Clin Pharmacol. 1990;39(3):227-32. doi: 10.1007/BF00315101.
5
Effects of once daily indapamide and pindolol on blood pressure, plasma aldosterone concentration and plasma renin activity in a general practice setting.在全科医疗环境中，每日一次吲达帕胺和吲哚洛尔对血压、血浆醛固酮浓度及血浆肾素活性的影响。
Eur J Clin Pharmacol. 1982;22(3):191-6. doi: 10.1007/BF00545213.
6
Indapamide in the treatment of essential arterial hypertension: results of a controlled study.吲达帕胺治疗原发性高血压：一项对照研究的结果。
Curr Med Res Opin. 1983;8 Suppl 3:59-66. doi: 10.1185/03007998309109837.
7
Diuretics, sodium intake, and renin in the management of hypertension.利尿剂、钠摄入与肾素在高血压治疗中的作用
J Cardiovasc Pharmacol. 1984;6 Suppl 1:S250-5. doi: 10.1097/00005344-198400061-00039.
8
A comparison of the effects of labetalol, bendrofluazide and their combination in hypertension.拉贝洛尔、苄氟噻嗪及其联合用药对高血压疗效的比较。
Br J Clin Pharmacol. 1979 Aug;8(2):149-54. doi: 10.1111/j.1365-2125.1979.tb05813.x.
9
Effect of indapamide on the renin-aldosterone system, and urinary excretion of potassium and calcium in essential hypertension.吲达帕胺对原发性高血压患者肾素 - 醛固酮系统及钾、钙尿排泄的影响。
Br J Clin Pharmacol. 1984 Aug;18(2):229-31. doi: 10.1111/j.1365-2125.1984.tb02458.x.
10
Comparative study on the antihypertensive efficacy of torasemide and indapamide in patients with essential hypertension.托拉塞米与吲达帕胺治疗原发性高血压患者降压疗效的对比研究。
Arzneimittelforschung. 1988 Jan;38(1A):190-3.
引用本文的文献
1
The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review.吲达帕胺与苄氟噻嗪治疗原发性高血压的效果比较：系统评价。
Br J Clin Pharmacol. 2019 Feb;85(2):285-303. doi: 10.1111/bcp.13787. Epub 2018 Nov 28.
2
Multifactorial hypokalaemia in a beer drinker.一名啤酒饮用者的多因素低钾血症
Ir J Med Sci. 1993 Jul;162(7):263-4. doi: 10.1007/BF02957575.
3
Indapamide. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.吲达帕胺。其药效学特性及治疗高血压疗效的综述。
Drugs. 1984 Sep;28(3):189-235. doi: 10.2165/00003495-198428030-00001.
4
Verapamil and bendrofluazide in the treatment of hypertension: a controlled study of effectiveness alone and in combination.维拉帕米和苄氟噻嗪治疗高血压：单独及联合用药疗效的对照研究
Eur J Clin Pharmacol. 1988;34(3):249-53. doi: 10.1007/BF00540951.
本文引用的文献
1
Why do thiazide diuretics lower blood pressure in essential hypertension?噻嗪类利尿剂为何能降低原发性高血压患者的血压？
Annu Rev Pharmacol. 1967;7:399-408. doi: 10.1146/annurev.pa.07.040167.002151.
2
Changes in plasma and extracellular fluid volumes in patients with essential hypertension during long-term treatment with hydrochlorothiazide.原发性高血压患者长期使用氢氯噻嗪治疗期间血浆和细胞外液容量的变化
Circulation. 1970 Sep;42(3):479-85. doi: 10.1161/01.cir.42.3.479.
3
Plasma renin and angiotensin II measurement in hypertensive and normal subjects: correlation of basal and stimulated states.
J Clin Endocrinol Metab. 1977 Jul;45(1):159-63. doi: 10.1210/jcem-45-1-159.
4
The renin response to diuretic therapyl A limitation of antihypertensive potential.利尿剂治疗时的肾素反应：抗高血压潜能的一种限制因素
Circ Res. 1978 Mar;42(3):376-81. doi: 10.1161/01.res.42.3.376.
5
Evaluation of indapamide in the treatment of hypertension.吲达帕胺治疗高血压的评估。
J Cardiovasc Pharmacol. 1979 Jul-Aug;1(4):389-94. doi: 10.1097/00005344-197907000-00001.
6
Salt intake and diuretic treatment of hypertension.高血压的盐摄入量与利尿剂治疗
Lancet. 1979 Jul 21;2(8134):121-3. doi: 10.1016/s0140-6736(79)90004-7.
Zotero 插件