Passeri M, Ferretti G, Monica C, Fanfani A, Bergamini N
Eur J Rheumatol Inflamm. 1981;4(1):36-40.
Twelve elderly in-patients undergoing chronic furosemide treatment (25 mg/day), with stable diuresis, were admitted to a cross-over, double-blind study to investigate the possible interactions between indoprofen and the diuretic. Indoprofen (200 mg t.i.d.) and identical placebo tablets were administered in randomized sequences for 4 days each. The sequence were preceded by a 4-day run-in observation period and followed by a 4-day follow-up. 24-hour urinary volume and the excretion of Na, K and endogenous creatinine were monitored, with serum Na, K, creatinine and creatinine clearance. Blood pressure and heart rate were measured and routine clinical blood chemistry tests and urinalysis were made for safety. The findings of this pilot study suggest that indoprofen does not alter the natriuretic action of furosemide; a tendency was noted towards a reduction of glomerular filtrate and urine volume, but the values after indoprofen were not significantly different from those after placebo.
12名接受慢性速尿治疗（25毫克/天）且利尿稳定的老年住院患者被纳入一项交叉双盲研究，以调查吲哚美辛与利尿剂之间可能的相互作用。吲哚美辛（200毫克，每日三次）和相同的安慰剂片剂以随机顺序给药，各给药4天。给药顺序之前有一个为期4天的导入观察期，之后有一个为期4天的随访期。监测24小时尿量以及钠、钾和内源性肌酐的排泄情况，并检测血清钠、钾、肌酐和肌酐清除率。测量血压和心率，并进行常规临床血液化学检查和尿液分析以确保安全。这项初步研究的结果表明，吲哚美辛不会改变速尿的利钠作用；注意到有肾小球滤过率和尿量降低的趋势，但吲哚美辛给药后的数值与安慰剂给药后的数值无显著差异。
