Bressan M A, Costantini M, Klersy C, Marangoni E, Meardi G, Panciroli C, Battaglia A, Bruni G, Sacchetti G
Int J Clin Pharmacol Ther Toxicol. 1985 Dec;23(12):668-72.
On the basis of the results of an earlier study, showing that i.v. indoprofen induced no clinically significant changes in hemodynamic parameters of patients with acute myocardial infarction (AMI), a double-blind randomized trial was carried out in 40 AMI patients to evaluate the analgesic activity of 400 mg i.v. indoprofen in comparison with 10 mg i.m. morphine hydrochloride. Pain severity was recorded before and at several intervals within 24 h after drug administration. The average analgesic response was prompt and progressive up to the 6th hour in both treatment groups, with no significant difference between drugs in various pain descriptors. However, the proportion of responding patients in indoprofen group was greater than in morphine group at all observation times, indicating a significant difference (p less than 0.05) in favor of indoprofen. In view of its good tolerability, i.v. indoprofen is worth considering in early AMI as an alternative to morphine in those patients in whom non-opiate analgesia might be preferable.
基于早期一项研究的结果，该研究表明静脉注射吲哚美辛对急性心肌梗死（AMI）患者的血流动力学参数无临床显著影响，我们对40例AMI患者进行了一项双盲随机试验，以评估静脉注射400 mg吲哚美辛与肌肉注射10 mg盐酸吗啡的镇痛活性。在给药前及给药后24小时内的几个时间点记录疼痛严重程度。两个治疗组的平均镇痛反应在第6小时前迅速且呈进行性，在各种疼痛描述指标上药物之间无显著差异。然而，在所有观察时间点，吲哚美辛组的有反应患者比例均高于吗啡组，表明支持吲哚美辛的显著差异（p小于0.05）。鉴于其良好的耐受性，对于那些可能更倾向于非阿片类镇痛的患者，静脉注射吲哚美辛在早期AMI中作为吗啡的替代药物值得考虑。
