Nissilä M, Jalava S, Groppi W
Eur J Rheumatol Inflamm. 1981;4(1):74-8.
Thirty in-patients suffering from classical or definite R.A. were given indoprofen 200 mg q.i.d., indomethacin 25 mg q.i.d. and placebo, according to a 6-line completely balanced block design. Each patient received the three treatments for ten days each. Patients were examined at baseline and after each treatment cycle. Both active drugs were significantly better than placebo on relief of pain, Ritchie index, and number of active, painful and swollen joints, morning stiffness; only indoprofen significantly improved grip strength. No significant differences were found between the two active drugs. The three treatments were well tolerated.
根据六行完全平衡区组设计，30例患有典型或确诊类风湿性关节炎（R.A.）的住院患者分别接受每日4次、每次200毫克的吲哚洛芬治疗，每日4次、每次25毫克的吲哚美辛治疗以及安慰剂治疗。每位患者每种治疗各接受10天。在基线期以及每个治疗周期结束后对患者进行检查。两种活性药物在缓解疼痛、里奇指数、活动关节、疼痛关节和肿胀关节数量以及晨僵方面均显著优于安慰剂；只有吲哚洛芬显著改善了握力。两种活性药物之间未发现显著差异。三种治疗的耐受性均良好。
