[Effect of stimulators of sexual function on the hypothalamo-hypophyseal system and the fertility of androgenized female rats].

Neonatal androgenization with 15--25 micrograms of testosterone-propyonate makes 43--54% of female rats sterile at puberty. Long-term administration of progesterone, clomiphen, luliberine, prostaglandin E2 induces ovulation but does not improve the fertility. Prostaglandin E2 decreases the amount of luliberine in the median emicnence and arquate nuclei within 30 min and increases the amount of luteinizing hormone in the blood of the control rats, whereas in the androgenized rats prostaglandin E2 is ineffective. According to the authors' hypothesis, a very mobile fraction of luliberine exists in the median emicnence, rapidly released into the portal blood system on stimulation and rather decreased in androgenization. Clomiphen increases the blood level of luteinizing hormone in the evening but its peak is twice as high in normal animals as compared with the androgenized ones.