Savchenko O N, Proĭmina F I, Danilova O A
Fiziol Zh SSSR Im I M Sechenova. 1982 Mar;68(3):411-7.
Neonatal androgenization with 15--25 micrograms of testosterone-propyonate makes 43--54% of female rats sterile at puberty. Long-term administration of progesterone, clomiphen, luliberine, prostaglandin E2 induces ovulation but does not improve the fertility. Prostaglandin E2 decreases the amount of luliberine in the median emicnence and arquate nuclei within 30 min and increases the amount of luteinizing hormone in the blood of the control rats, whereas in the androgenized rats prostaglandin E2 is ineffective. According to the authors' hypothesis, a very mobile fraction of luliberine exists in the median emicnence, rapidly released into the portal blood system on stimulation and rather decreased in androgenization. Clomiphen increases the blood level of luteinizing hormone in the evening but its peak is twice as high in normal animals as compared with the androgenized ones.
用15 - 25微克丙酸睾酮对新生大鼠进行雄激素化处理，可使43% - 54%的雌性大鼠在青春期不育。长期给予孕酮、氯米芬、促黄体素释放激素、前列腺素E2可诱导排卵，但不能提高生育能力。前列腺素E2在30分钟内可降低正中隆起和弓状核中促黄体素释放激素的含量，并增加对照大鼠血液中促黄体生成素的含量，而在雄激素化大鼠中前列腺素E2无效。根据作者的假设，正中隆起中存在一部分极易移动的促黄体素释放激素，受到刺激后会迅速释放到门静脉血液系统中，而在雄激素化状态下其含量会减少。氯米芬可在傍晚提高促黄体生成素的血液水平，但其峰值在正常动物中是雄激素化动物的两倍。
