[Role of 5-alpha-androstane-3-beta, 17-beta-diol in establishing feedback between the gonads and hypothalamo-hypophyseal system of orchidectomized adult rats].

Concentration of luteinizing hormone and content of luliberine were estimated, respectively, blood serum and in hypothalamic arccuate nucleus and median eminence of adult castrated rats after administration of testosterone, 5 alpha-androstane 3 beta, 17 beta diol and 5 alpha-androstane 3 alpha, 17 beta diol. Effect of testosterone and of its derivatives on hypothalamo-hypophysial system was distinctly dissimilar both in the intensity of the action and in the rate of its realization. 5 alpha-androstane 3 beta, 17 beta diol as well as testosterone and 5 alpha-androstane 3 alpha, 17 beta diol were shown to be active in the negative feedback mechanism between gonads and hypothalamo-hypophysial system; the effect of androgenes was dose-dependent.