Freeman G B, Wallace R B, Werboff J, Graziadei R B, Root M, Smith P, Warner N W
Percept Mot Skills. 1978 Aug;47(1):163-7. doi: 10.2466/pms.1978.47.1.163.
13 male Long-Evans hooded rats were tested on a CRF-50 reinforcement schedule. Total response time as well as time and total activity responses away from the bar were significantly influenced by injections of methylphenidate (1.2 mg/kg I.P.). In general, the data supported previous findings of reduced response rate to the drug. However, methylphenidate (a CNS stimulant) increased activity that was not related to bar pressing. Analysis of activity response to drug should include total time and activity as well as operant rates.
13只雄性Long-Evans有帽大鼠按照50%固定比率强化程序进行测试。腹腔注射哌甲酯（1.2毫克/千克）显著影响了总反应时间以及离开杠杆的时间和总活动反应。总体而言，数据支持了先前关于药物反应率降低的研究结果。然而，哌甲酯（一种中枢神经系统兴奋剂）增加了与按压杠杆无关的活动。对药物活动反应的分析应包括总时间、活动以及操作率。
