大肠杆菌释放不耐热肠毒素亚基。
Release of heat-labile enterotoxin subunits by Escherichia coli.
作者信息
Yamamoto T, Yokota T
出版信息
J Bacteriol. 1982 Jun;150(3):1482-4. doi: 10.1128/jb.150.3.1482-1484.1982.
Abstract
Most of the heat-labile enterotoxin (LT) synthesized by Escherichia coli is cell associated; however, a small portion of LT (approximately 10%) is released by bacterial cells into the culture supernatant. The LT subunit B (LT-B) produced by a cloned LT-B gene (tox B) was released in amounts equal to the parent LT release. In contrast, no release of LT subunit A (LT-A) or its smaller derivatives was observed in strains containing cloned toxA genes. The data suggest that LT-B is necessary for the release of LT-A across the bacterial membrane.
摘要
大肠杆菌合成的大多数热不稳定肠毒素（LT）与细胞相关；然而，一小部分LT（约10%）由细菌细胞释放到培养上清液中。由克隆的LT-B基因（tox B）产生的LT亚基B（LT-B）的释放量与亲本LT的释放量相等。相比之下，在含有克隆toxA基因的菌株中未观察到LT亚基A（LT-A）或其较小衍生物的释放。数据表明，LT-B是LT-A跨细菌膜释放所必需的。
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