Orlov V N, Chigrinova L S
Kardiologiia. 1982 Mar;22(3):53-7.
In 78 patients with ischaemic heart disease prior to and after treatment with obsidan the authors examined relationship between the indices of activity of the sympatho-adrenal and renin systems. A correlation analysis was made between the data adrenalin excretion, noradrenalin, dopamine and DOPA in the urine and renin activity in the blood. After obsidan treatment the excretion of adrenaline and renin activity in blood plasma diminish. After obsidan treatment different links of activity of the sympato-adrenal system function more conjointly. Change in the activity of one of the links produces corresponding changes in the activity of the others. Dependence of renin activity is shown to exist on the activity of the sympatho-adrenal system after treatment as compared to their levels prior to treatment . The initial background recorded prior to treatment influences significantly the final result of treatment. A negative correlation exists between the activity of the sympatho-adrenal system and renin which is regarded as evidence of protective compensatory reaction of the body. It is suggested that the increase of noradrenalin secretion, causing rise of the blood pressure is associated with the compensatory decrease of renin activity.
在78例缺血性心脏病患者中，作者观察了在使用奥西丹治疗前后交感 - 肾上腺系统和肾素系统活性指标之间的关系。对尿中肾上腺素、去甲肾上腺素、多巴胺和多巴的排泄数据与血液中肾素活性进行了相关分析。使用奥西丹治疗后，血浆中肾上腺素排泄和肾素活性降低。使用奥西丹治疗后，交感 - 肾上腺系统功能的不同环节协同作用更强。其中一个环节活性的变化会引起其他环节活性的相应变化。与治疗前水平相比，治疗后肾素活性显示出依赖于交感 - 肾上腺系统的活性。治疗前记录的初始背景显著影响治疗的最终结果。交感 - 肾上腺系统活性与肾素之间存在负相关，这被视为机体保护性代偿反应的证据。提示去甲肾上腺素分泌增加导致血压升高与肾素活性的代偿性降低有关。
