[Indices of sympathetic-adrenal system and renin activity in ischemic heart disease before and after obzidan treatment].

In 78 patients with ischaemic heart disease prior to and after treatment with obsidan the authors examined relationship between the indices of activity of the sympatho-adrenal and renin systems. A correlation analysis was made between the data adrenalin excretion, noradrenalin, dopamine and DOPA in the urine and renin activity in the blood. After obsidan treatment the excretion of adrenaline and renin activity in blood plasma diminish. After obsidan treatment different links of activity of the sympato-adrenal system function more conjointly. Change in the activity of one of the links produces corresponding changes in the activity of the others. Dependence of renin activity is shown to exist on the activity of the sympatho-adrenal system after treatment as compared to their levels prior to treatment . The initial background recorded prior to treatment influences significantly the final result of treatment. A negative correlation exists between the activity of the sympatho-adrenal system and renin which is regarded as evidence of protective compensatory reaction of the body. It is suggested that the increase of noradrenalin secretion, causing rise of the blood pressure is associated with the compensatory decrease of renin activity.