Paulus J M, Casals F J
Nouv Rev Fr Hematol (1978). 1978 Jun 10;20(2):151-4.
Platelet size distribution and survival parameters were studied in control subjects and ten subjects presenting Mediterranean macrothrombocytosis. The comparison showed that the latter group maintains a normal platelet circulating mass (thrombocytocrit) by combining normal platelet survival, increased splenic pooling and production of a reduced number of greatly enlarged cells. In addition to offering new insight into the megakaryocytic mechanisms that determine platelet size, the study of Mediterranean macrothrombocytosis indicates that platelet size distributions and survival parameters should be integrated in order to provide a meaningful picture of human platelet kinetics.
在对照组和十名患有地中海大血小板增多症的受试者中研究了血小板大小分布和存活参数。比较结果显示，后一组通过正常的血小板存活、增加的脾脏池化以及产生数量减少但体积大幅增大的细胞，维持了正常的血小板循环量（血小板压积）。除了为决定血小板大小的巨核细胞机制提供新的见解外，对地中海大血小板增多症的研究表明，应整合血小板大小分布和存活参数，以便提供人类血小板动力学的有意义图景。
