Zhurova T E
Probl Endokrinol (Mosk). 1982 Mar-Apr;28(2):21-6.
Comparative studies of the glucagon-, OTTG- and BTTG tolerance test were performed in 50 patients, aged 25 to 50 years, glucagon being injected after intravenous and peroral glucose loading at hyperglycemic peak height. It was detected that a single intravenous glucagon injection provokes hyperglycemia mostly in healthy subjects than in patients with thyrotoxicosis during the first 15 to 30 minutes. Stimulating effect on insulin secretion was the same. Glucagon injection does not enhance glucose-induced hyperglycemia after peroral glucose loading and intensifies insulin rise rather than separate glucagon or glucose use. Combined glucagon-glucose administration produced tension in the insular apparatus alpha-cell function, that allows one to recommend this diagnostic test for determining reserve functional possibilities of Langerhans' islets in thyrotoxicosis-suffering patients with normal glucose tolerance under clinical conditions.
对50名年龄在25至50岁之间的患者进行了胰高血糖素、口服葡萄糖耐量（OTTG）和静脉葡萄糖耐量（BTTG）试验的对比研究，在高血糖峰值高度时静脉和口服葡萄糖负荷后注射胰高血糖素。结果发现，单次静脉注射胰高血糖素在最初15至30分钟内引发高血糖的情况在健康受试者中比在甲状腺毒症患者中更为常见。对胰岛素分泌的刺激作用相同。口服葡萄糖负荷后，注射胰高血糖素不会增强葡萄糖诱导的高血糖，而是增强胰岛素升高，而不是单独使用胰高血糖素或葡萄糖。联合使用胰高血糖素和葡萄糖会使胰岛α细胞功能紧张，这使得可以推荐这种诊断测试，以在临床条件下确定葡萄糖耐量正常的甲状腺毒症患者中朗格汉斯胰岛的储备功能可能性。
