Camus P
Rev Fr Mal Respir. 1982;10(1):7-20.
The literature is reviewed on patients developing respiratory symptoms while receiving D-Penicillamine, most of whom suffered from rheumatoid arthritis. The manifestations were (in decreasing frequency) bronchiolitis obliterans, interstitial pneumonitis, a Good pasture's like syndrome and bronchospasm. For each complication we discuss diagnostic criteria, the implication of the drug and the pathogenesis. In addition we make suggestions regarding patients on D-Penicillamine and emphasize the need for accurate reporting of adverse pulmonary effects to enlarge the epidemiological picture.
本文回顾了接受青霉胺治疗时出现呼吸道症状的患者的相关文献，其中大多数患者患有类风湿性关节炎。其表现（按出现频率递减）为闭塞性细支气管炎、间质性肺炎、类Goodpasture综合征和支气管痉挛。对于每种并发症，我们讨论了诊断标准、药物的影响及发病机制。此外，我们对服用青霉胺的患者提出了建议，并强调准确报告肺部不良反应以扩大流行病学认识的必要性。
