Overturf M L, Sybers H D, Druilhet R E, Smith S A, Kirkendall W M
Res Commun Chem Pathol Pharmacol. 1982 Apr;36(1):169-72.
The effects of the converting enzyme (CE) inhibitor, captopril, on blood pressure, plasma aldosterone, plasma renin activity (PRA), and kidney morphology were studied. Captopril, at a near maximum daily recommended human dose of approximately 5.0 mg/kg, was administered to rabbits over a period of six months. Mean arterial pressure, CE activity, and aldosterone levels were significantly reduced; PRA and renal renin activity were increased. Microscopic examination of the kidney showed marked hyperplasia of the juxtaglomerular apparatus in all of the treated animals.
研究了转化酶（CE）抑制剂卡托普利对血压、血浆醛固酮、血浆肾素活性（PRA）和肾脏形态的影响。以接近每日最大推荐人用剂量约5.0mg/kg的卡托普利对兔子给药六个月。平均动脉压、CE活性和醛固酮水平显著降低；PRA和肾素活性升高。对肾脏的显微镜检查显示，所有治疗动物的肾小球旁器均有明显增生。
