Kaneta M, Abe K, Ito T
Jpn Circ J. 1983 Sep;47(9):1071-6. doi: 10.1253/jcj.47.1071.
In mice, the juxtaglomerular cells were examined using qualitative and quantitative electron microscopy after an administration of captopril. After treatment with captopril for 2, 7 and 14 days, the specific granules were decreased in number, the Golgi apparatus was well developed, and the rough endoplasmic reticulum was dilated in profile. In the dilated rough endoplasmic reticulum, the intracisternal granules were occasionally seen after a 2-day treatment, were increased in size and number after a 7-day treatment and were hardly seen after a 14-day treatment. In a few cells associated with intracisternal granules on the 7th day, the Golgi apparatus was not well developed and some lysosomal bodies containing granules similar to the intracisternal granules were seen. In these cells, an excess of the intracisternal granules may be controlled by lysosomes. These findings suggest that the juxtaglomerular cells stimulate renin synthesis after long-term treatment with captopril, but a further increase in renin synthesis cannot be expected after the 7th day.
在小鼠中，给予卡托普利后，使用定性和定量电子显微镜检查肾小球旁细胞。用卡托普利治疗2、7和14天后，特异性颗粒数量减少，高尔基体发育良好，粗面内质网轮廓扩张。在扩张的粗面内质网中，2天治疗后偶尔可见池内颗粒，7天治疗后其大小和数量增加，14天治疗后几乎不见。在第7天与池内颗粒相关的少数细胞中，高尔基体发育不良，可见一些含有与池内颗粒相似颗粒的溶酶体。在这些细胞中，过量的池内颗粒可能由溶酶体控制。这些发现表明，长期用卡托普利治疗后，肾小球旁细胞刺激肾素合成，但第7天后肾素合成不能期望进一步增加。
