Stebbing A R
Sci Total Environ. 1982 Feb;22(3):213-34. doi: 10.1016/0048-9697(82)90066-3.
Hormesis is the name given to the stimulatory effects caused by low levels of potentially toxic agents. When this phenomenon was first identified it was called the Arndt-Schulz Law or Hueppe's Rule because it was thought to occur generally. Although this generalisation is not accepted today, there has never been more evidence in its support, justifying a re-examination of the phenomenon. Evidence from the literature shows that not only has growth hormesis been observed in a range of taxa after exposure to a variety of agents, but also that the dose-response data have a consistent form. While there are a number of separate hypotheses to explain specific instances of hormesis, the evidence presented here suggests that different examples might have a common explanation, and the possibility of a general theory is considered.
毒物兴奋效应是指低水平的潜在毒性物质所产生的刺激作用。当这一现象首次被发现时，它被称为阿恩特 - 舒尔茨定律或胡佩法则，因为当时认为它普遍存在。尽管如今这种一概而论的观点未被接受，但支持它的证据从未像现在这样多，这使得有理由对该现象进行重新审视。文献证据表明，不仅在一系列生物分类群中，在接触多种物质后观察到了生长毒物兴奋效应，而且剂量反应数据具有一致的形式。虽然有许多不同的假说来解释毒物兴奋效应的具体实例，但此处所呈现的证据表明，不同的例子可能有一个共同的解释，并且人们考虑了建立一个通用理论的可能性。
