Hobitz H
Wien Klin Wochenschr. 1982 Feb 5;94(3):67-75.
The chemistry and identity of fully synthetic human calcitonin are discussed briefly, with particular reference to the evolution of this hormone. The principal effects of the substance on bone demonstrable by clinicochemical means are illustrated by the results of clinicopharmacological studies in patients suffering from Paget's disease. The potential usefulness of calcitonin in the treatment of osteoporosis is exemplified by reference to the relations between sex hormones and calcitonin. The main differences in the acute effects of calcitonin on the kidney and electrolyte balance in healthy persons and patients with Paget's disease are analysed on the basis of data from comparative human pharmacological and clinicopharmacological studies.
本文简要讨论了全合成人降钙素的化学性质和特性，尤其涉及其激素的演变过程。通过临床化学方法证实的该物质对骨骼的主要作用，以患有佩吉特氏病患者的临床药理学研究结果为例进行说明。通过参考性激素与降钙素之间的关系，举例说明了降钙素在治疗骨质疏松症方面的潜在用途。基于人体比较药理学和临床药理学研究数据，分析了降钙素对健康人和佩吉特氏病患者肾脏及电解质平衡的急性作用的主要差异。
