Kir'ianov N A
Arkh Patol. 1982;44(4):71-4.
Tumor cells in lymphogranulomatosis include Hodgkin's cells, Berezovsky-Shternberg cells and variants thereof representing a single population characterized by aneuploidy, polyploidy, and marker chromosomes. All cells of this clone are capable of DNA synthesis and mitotic division. As the disease progresses, the number of tumor cells increases gradually. Their origin is still obscure. The hypotheses of their origin from B-lymphocytes because of the presence in them of cytoplasmic and surface immunoglobulins and also from macrophages because cells of tissue culture from tumor nodes were found to have nonspecific esterase, lysozyme, capacity for phagocytosis seem to be substantiated.
淋巴肉芽肿病中的肿瘤细胞包括霍奇金细胞、贝雷佐夫斯基-施特恩伯格细胞及其变体，它们代表了一个以非整倍体、多倍体和标记染色体为特征的单一细胞群。该克隆的所有细胞都能够进行DNA合成和有丝分裂。随着疾病进展，肿瘤细胞数量逐渐增加。它们的起源仍然不明。关于其起源的假说，因肿瘤细胞中存在细胞质和表面免疫球蛋白而认为起源于B淋巴细胞，又因在肿瘤结节的组织培养细胞中发现有非特异性酯酶、溶菌酶及吞噬能力而认为起源于巨噬细胞，这些假说似乎都有一定依据。
