胰岛素与经四氧嘧啶诱导成糖尿病的大鼠肝脏质膜的结合。两类相互处于平衡状态的结合位点的动力学证明。
Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other.
作者信息
Corin R E, Donner D B
出版信息
Biochem J. 1982 Jan 15;202(1):259-62. doi: 10.1042/bj2020259.
Abstract
The association of 125I-labelled insulin with liver plasma membranes from diabetic rats was consistent with more than one compartment of binding. After a short association period, insulin dissociation comprised rapid and slow phases. After a long association period, dissociation was only at a slow rate. Lower-affinity hormone-receptor complexes were converted to higher-affinity complexes as the time of occupancy lengthened.
摘要
125I标记的胰岛素与糖尿病大鼠肝细胞膜的结合符合不止一个结合区室的情况。在短时间结合期后，胰岛素解离包括快速和慢速阶段。在长时间结合期后，解离仅以缓慢速率进行。随着占据时间延长，低亲和力的激素-受体复合物会转变为高亲和力复合物。
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Insulin binding to liver plasma membranes from rats rendered diabetic by alloxan. A kinetic demonstration of two classes of binding sites in equilibrium with each other.胰岛素与经四氧嘧啶诱导成糖尿病的大鼠肝脏质膜的结合。两类相互处于平衡状态的结合位点的动力学证明。
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本文引用的文献
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Affinity of the hepatic insulin receptor is influenced by membrane phospholipids.肝胰岛素受体的亲和力受膜磷脂的影响。
J Biol Chem. 1981 Nov 10;256(21):11051-7.
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LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective.1980年礼来讲座。胰岛素抵抗与胰岛素作用。体外和体内视角。
Diabetes. 1981 Feb;30(2):148-62. doi: 10.2337/diab.30.2.148.
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REgulation of insulin binding to isolated hepatocytes: correction for bound hormone fragments linearizes Scatchard plots.胰岛素与分离的肝细胞结合的调节：对结合的激素片段进行校正可使Scatchard图线性化。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3176-80. doi: 10.1073/pnas.77.6.3176.
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Formation of a receptor state from which insulin dissociates slowly in hepatic cells and plasma membranes.在肝细胞和质膜中形成一种受体状态，胰岛素从该状态缓慢解离。
J Biol Chem. 1980 Oct 10;255(19):9005-8.
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Postreceptor alterations in the states of insulin resistance.胰岛素抵抗状态下的受体后改变。
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Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.肝细胞膜中胰岛素受体相互作用的定量研究
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