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视觉功能障碍的组织病理学和实验室评估。

Histopathological and laboratory assessment of visual dysfunction.

作者信息

Heywood R

出版信息

Environ Health Perspect. 1982 Apr;44:35-45. doi: 10.1289/ehp.824435.

DOI:10.1289/ehp.824435
PMID:7044774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1568961/
Abstract

The currently available methods of assessing ocular toxicity are discussed. Manifestations of ocular toxicity are best described clinically; histopathological examination of the eye is beset with problems of preparing the eye for morphological examinations. Electron microscopy is essential to look for chemically induced side effects at the cellular level. Mechanisms of ocular toxicity are poorly understood, and the limitation of animal studies in predicting side effects in man must be appreciated.

摘要

本文讨论了目前可用的评估眼毒性的方法。眼毒性的表现最好通过临床来描述；眼部的组织病理学检查在为形态学检查准备眼睛方面存在诸多问题。电子显微镜对于在细胞水平上寻找化学诱导的副作用至关重要。眼毒性的机制尚不清楚，必须认识到动物研究在预测人类副作用方面的局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/9b88bf34df63/envhper00461-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/15e4c04d68f6/envhper00461-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/004767a952a4/envhper00461-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/30d75c2af1fe/envhper00461-0044-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/8d4e0cdffc10/envhper00461-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/06283ad0854f/envhper00461-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/a5885eb25b95/envhper00461-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/5fbc2d8c70bc/envhper00461-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/7ac79eb9a9ec/envhper00461-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/9b88bf34df63/envhper00461-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/15e4c04d68f6/envhper00461-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/004767a952a4/envhper00461-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/30d75c2af1fe/envhper00461-0044-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/8d4e0cdffc10/envhper00461-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/06283ad0854f/envhper00461-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/a5885eb25b95/envhper00461-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/5fbc2d8c70bc/envhper00461-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/7ac79eb9a9ec/envhper00461-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d88/1568961/9b88bf34df63/envhper00461-0049-a.jpg

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引用本文的文献

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Pathogenesis and reversibility of retinopathy induced by 1,4-bis (4-aminophenoxy)-2-phenylbenzene (2-phenyl-APB-144) in pigmented rats.1,4-双（4-氨基苯氧基）-2-苯基苯（2-苯基-APB-144）诱导的色素沉着大鼠视网膜病变的发病机制及可逆性
Arch Toxicol. 1991;65(4):292-303. doi: 10.1007/BF01968963.

本文引用的文献

1
Notes on Technique for Postmortem Examination of the Eye.眼部尸体解剖技术笔记
Can Vet J. 1961 Apr;2(4):123-9.
2
FURTHER STUDIES CONCERNING THE ACCUMULATION OF POLYCYCLIC COMPOUNDS ON UVEAL MELANIN.关于多环化合物在葡萄膜黑色素上积累的进一步研究
Invest Ophthalmol. 1964 Aug;3:399-404.
3
ETHAMBUTOL-INDUCED TRANSIENT CHANGE AND RECONSTITUTION (IN VIVO) OF THE TAPETUM LUCIDUM COLOR IN THE DOG.乙胺丁醇引起的犬眼脉络膜视网膜毯颜色的短暂变化及恢复（体内实验）
Exp Mol Pathol Suppl. 1963 Dec;2:136-49.
4
Chromodacryorrhea in laboratory rats (Rattus norvegicus): etiologic considerations.实验大鼠（褐家鼠）的泪溢性色泪症：病因学探讨
Lab Anim Sci. 1980 Oct;30(5):841-4.
5
The effect of hexachlorophene on the optic nerve and visual faculty in Beagle dogs after prolonged dermal application.长期经皮应用六氯酚对比格犬视神经和视觉功能的影响。
Toxicol Lett. 1980 Jan;5(1):77-82. doi: 10.1016/0378-4274(80)90151-4.
6
Occurrence of corneal opacities in rats after acute administration of l-alpha-acetylmethadol.急性给予左旋 -α- 乙酰美沙多后大鼠角膜混浊的发生情况。
Toxicol Appl Pharmacol. 1980 Nov;56(2):155-63. doi: 10.1016/0041-008x(80)90285-9.
7
Induced corneal opacities in the rat.大鼠诱导性角膜混浊
Br J Ophthalmol. 1967 Feb;51(2):124-9. doi: 10.1136/bjo.51.2.124.
8
Dimethyl sulfoxide: lens changes in dogs during oral administration.二甲基亚砜：犬口服给药期间的晶状体变化
Science. 1966 Jul 1;153(3731):83-4. doi: 10.1126/science.153.3731.83.
9
Experimental papilledema in the dog induced by a salicylanilide.由水杨酰苯胺诱发的犬实验性视乳头水肿。
Toxicol Appl Pharmacol. 1972 Apr;21(4):532-41. doi: 10.1016/0041-008x(72)90009-9.
10
Ocular studies with para-chlorophenylalanine in rats and monkeys.对大鼠和猴子进行的对氯苯丙氨酸眼部研究。
Arch Ophthalmol. 1970 Jun;83(6):734-40. doi: 10.1001/archopht.1970.00990030734012.