Staben P
Toxicol Lett. 1980 Jan;5(1):77-82. doi: 10.1016/0378-4274(80)90151-4.
In a systemic tolerance study in Beagle dogs the effect of an ointment, containing 1, 3 or 10% hexachlorophene (HCP), applied dermally, on the optic system over a period of 12 weeks was investigated. Besides an irreversible loss of visual faculty during treatment with 3 and 10% HCP, a permanent mydriasis, peripapillary exudations and other alterations of the ocular fundus were observed at the same dose levels, suggesting that HCP has a strong affinity to the optic nervous system in dogs without clear-cut correlations to HCP plasma levels.
在一项针对比格犬的全身耐受性研究中，研究了一种含有1%、3%或10%六氯酚（HCP）的软膏经皮给药12周对视觉系统的影响。除了在使用3%和10% HCP治疗期间出现不可逆的视力丧失外，在相同剂量水平下还观察到永久性瞳孔散大、视乳头周围渗出以及眼底的其他改变，这表明HCP对犬的视觉神经系统具有很强的亲和力，且与HCP血浆水平无明确相关性。
