Dvoretsky P, Wood G S, Levy R, Warnke R A
Hum Pathol. 1982 Jul;13(7):618-25. doi: 10.1016/s0046-8177(82)80003-8.
Using monoclonal antibodies on frozen sections, the authors define the anatomic localization of T-lymphocyte subsets in follicular lymphomas as well as in nonneoplastic lymph nodes and tonsils. The percentage of Leu-1+ T cells in the follicles of follicular lymphomas (20 per cent) was virtually identical to that seen in the follicles of nonneoplastic lymph nodes or tonsils (22 per cent). There were 50 per cent T cells in the interfollicular regions of follicular lymphomas and 75 per cent in the paracortical regions of the nonneoplastic specimens. In neoplastic follicles the number of Leu-3a+ cells was 67 per cent of the number of Leu-1+ cells, whereas, virtually the entire T-cell population in the nonneoplastic follicles expressed the Leu-3a antigen. These T cells of helper phenotype may facilitate the neoplastic process or an immune response against it or may be bystanders to the B-cell proliferation. Hum Pathol 13:618-625, 1982
作者利用针对冰冻切片的单克隆抗体，确定了T淋巴细胞亚群在滤泡性淋巴瘤以及非肿瘤性淋巴结和扁桃体中的解剖定位。滤泡性淋巴瘤滤泡中Leu-1 + T细胞的百分比（20%）与非肿瘤性淋巴结或扁桃体滤泡中的百分比（22%）几乎相同。滤泡性淋巴瘤的滤泡间区域有50%的T细胞，非肿瘤性标本的副皮质区域有75%的T细胞。在肿瘤性滤泡中，Leu-3a +细胞的数量是Leu-1 +细胞数量的67%，而在非肿瘤性滤泡中，几乎所有T细胞群体都表达Leu-3a抗原。这些具有辅助表型的T细胞可能促进肿瘤形成过程或针对肿瘤的免疫反应，或者可能是B细胞增殖的旁观者。《人类病理学》1982年第13卷：618 - 625页
