Meyer E M, Barrnett R J, Cooper J R
J Neurochem. 1982 Aug;39(2):321-6. doi: 10.1111/j.1471-4159.1982.tb03950.x.
An analog of choline, in which nitrogen was replaced by antimony, was neurochemically characterized in rat cortical synaptosomes. It was found to be a substrate for several cholinergic enzymes, transported by a Na+-dependent, hemicholinium-3-sensitive process, acetylated, and subsequently released by depolarization in a calcium-dependent manner. Sb-choline also completed with choline for Na+-dependent uptake and for acetylation by [14C]acetyl-CoA in synaptosomes. These results suggest that Sb-choline and its acetylated product should be useful substrates for the x-ray microanalytical localization of cholinergic pools in intact nerve terminals.
一种胆碱类似物，其中氮被锑取代，已在大鼠皮质突触体中进行了神经化学特征分析。发现它是几种胆碱能酶的底物，通过钠依赖性、对半胱氨酸-3敏感的过程进行转运、乙酰化，随后以钙依赖性方式通过去极化释放。锑胆碱还与胆碱竞争突触体中钠依赖性摄取和[14C]乙酰辅酶A的乙酰化作用。这些结果表明，锑胆碱及其乙酰化产物应是完整神经末梢中胆碱能池X射线微分析定位的有用底物。
