The chemical activation of non-mutagenic nitrated polycyclic aromatic hydrocarbons to mutagens.
作者信息
Karpinsky G E, McCoy E C, Rosenkranz H S, Mermelstein R
出版信息
Mutat Res. 1982 Feb 22;92(1-2):29-37. doi: 10.1016/0027-5107(82)90207-x.
PMID:7045649
Abstract
Nitrated polycyclic aromatic hydrocarbons, including carcinogens, may be non-mutagenic in microorganisms because bacterial nitroreductases are unable to reduce their nitro function to proximate mutagenic hydroxylamines. This reduction of the nitro moiety can be accomplished chemically in situ using zinc dust. The procedure, which is compatible with the Salmonella mutagenicity assay, was used to generate mutagens from chemicals which otherwise are non-mutagenic even in the presence of microsomal preparations.
摘要
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