[Filling skull defects with regenerating bone].

A destruction method was elaborated in dog experiments which allowed bone defects in the skull to be repaired with regenerating bone. The bone is ground to fillings, moistened with the recipient's blood, and implanted in the bone defect in the skull onto the dura mater which is necessary for bone regeneration. The bone fillings dissolve within 7 days, their cells perish and the substances released from them induce osteogenesis in the cells of the immature connective tissue. Fresh bone filings may be used for auto-, allo- and heteroplasty. They preserve their osteo-inducing property after freezing at--78 degrees C and are inactivated after being autoclaved and treated with 0.5% formaldehyde solution or diocide solution. Lyophilization reduces the osteo-inducing property of bone fillings.