Erkkola R, Lammintausta R, Liukko P, Anttila M
Acta Obstet Gynecol Scand. 1982;61(1):31-4. doi: 10.3109/00016348209156947.
Eighty milligrams of propranolol or sotalol was administered orally to two groups of 8 parturients who were to undergo elective cesarean section. This was performed 3 hours after drug administration. The transplacental passage of both drugs was registered in each patient. The maternal concentration of propranolol was approximately four times that in the umbilical circulation, while the sotalol level in maternal circulation was twice that in the umbilical circulation. The administration of beta-adrenoceptor antagonists caused a significant decrease in maternal plasma renin activity. After these doses of beta blockers, no difference in the plasma renin activity was found in the umbilical circulation, when compared with the previous normal values at cesarean section.
给两组各8名计划进行择期剖宫产的产妇口服80毫克普萘洛尔或索他洛尔。给药3小时后进行剖宫产。记录每位患者中两种药物的经胎盘转运情况。普萘洛尔的母体浓度约为脐循环浓度的四倍，而索他洛尔在母体循环中的水平是脐循环中的两倍。β肾上腺素能受体拮抗剂的给药导致母体血浆肾素活性显著降低。给予这些剂量的β受体阻滞剂后，与剖宫产时先前的正常值相比，脐循环中的血浆肾素活性未发现差异。
