Cottrill C M, McAllister R G, Gettes L, Noonan J A
J Pediatr. 1977 Nov;91(5):812-4. doi: 10.1016/s0022-3476(77)81049-4.
The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant. The neonate's plasma propranolol level rose from 40 ng/ml at the time of birth to 90 ng/ml four hours later. This increase in plasma propranolol concentration might be due to redistribution of the drug in the neonate as well as to different elimination mechanisms than in adults. The elevated propranolol level four hours after delivery was not associated with any signs or symptoms of drug toxicity, but drug effect was apparent on the electrocardiogram. The administration of propranolol during pregnancy in doses capable of producing therapeutic maternal blood levels may be dangerous to the neonate.
孕期、分娩期给予160毫克普萘洛尔与一名新生儿严重低血糖和呼吸抑制有关。新生儿出生时血浆普萘洛尔水平为40纳克/毫升，4小时后升至90纳克/毫升。血浆普萘洛尔浓度的这种升高可能是由于药物在新生儿体内重新分布以及与成人不同的消除机制所致。分娩后4小时普萘洛尔水平升高与任何药物毒性体征或症状均无关，但心电图上有明显的药物效应。孕期给予能使母体血液达到治疗水平剂量的普萘洛尔可能对新生儿有危险。
