French W J, Garner D, Hockett D, Laks M M
Am Heart J. 1982 Jul;104(1):104-8. doi: 10.1016/0002-8703(82)90648-2.
Ventriculographically derived ejection fraction (EF-V) is the most frequently used method to measure left ventricular (LV) function, However, significant error may result in the measurement of end-systolic volume (ESV), which is used to calculate EF-V. This error is ascribed to the variable, irregular, nonellipsoidal geometry of the end-systolic ventricular chamber. Since stroke volume (SV) is determined more accurately by dilution methods than by ventriculography, an improved measure of ESV can be calculated by subtracting green dye determined SV from the ventriculographic determined end-diastolic volume (EDV). The purpose of this study was to measure a correlated ejection fraction (EF-C) using EDV by ventriculography and SV derived using green dye. In eight anesthesized dogs cardiac outputs (COs) were calculated by green dye and left ventriculography. CO determined by ventriculography was greater than that measured by green dye (p less than 0.005). EF-V (55 +/- 15%) was always greater than EF-C (32 +/- 12%) (p less than 0.005). These studies (1) may partially explain the discrepancy in CO calculated from the use of dilution methods and ventriculography and (2) present a method to improve the calculation of LV ejection fraction.
心室造影衍生射血分数（EF-V）是测量左心室（LV）功能最常用的方法。然而，用于计算EF-V的收缩末期容积（ESV）测量可能会产生显著误差。这种误差归因于收缩末期心室腔可变、不规则、非椭圆形的几何形状。由于通过稀释法测定每搏输出量（SV）比心室造影更准确，因此可以通过从心室造影测定的舒张末期容积（EDV）中减去绿色染料测定的SV来计算更准确的ESV。本研究的目的是使用心室造影的EDV和绿色染料衍生的SV来测量相关射血分数（EF-C）。在八只麻醉犬中，通过绿色染料和左心室造影计算心输出量（CO）。心室造影测定的CO大于绿色染料测定的CO（p<0.005）。EF-V（55±15%）总是大于EF-C（32±12%）（p<0.005）。这些研究（1）可能部分解释了使用稀释法和心室造影计算的CO之间的差异，（2）提出了一种改进左心室射血分数计算的方法。
