Ahmed A R
Arch Dermatol. 1982 Jul;118(7):521-5.
Human infection is the result of a complex interplay of factors pertaining to the invading organism, the host, and the environment. This is best shown in human dermatophyte infections. Acute infections are usually short-lived and easy to treat. The patient has good cell-mediated immunity, short-term antidermatophyte antibodies, and delayed hypersensitivity. In chronic infections, the infection is long-term and resistant to therapy. Patients have poor in vitro assessed cell-mediated immunity and immediate hypersensitivity to fungal antigens. Antidermatophyte antibodies usually do not disappear quickly. Development of more specific and sensitive assays will add to our understanding of this unique host-parasite relationship. The speculative role of anti-idiotypic antibodies is discussed.
人类感染是与入侵生物体、宿主和环境相关的多种因素复杂相互作用的结果。这在人类皮肤癣菌感染中表现得最为明显。急性感染通常病程短暂且易于治疗。患者具有良好的细胞介导免疫、短期抗皮肤癣菌抗体以及迟发型超敏反应。在慢性感染中，感染是长期的且对治疗具有抗性。患者体外评估的细胞介导免疫较差，对真菌抗原有速发型超敏反应。抗皮肤癣菌抗体通常不会迅速消失。开发更特异、更灵敏的检测方法将增进我们对这种独特宿主 - 寄生虫关系的理解。文中讨论了抗独特型抗体的推测作用。
