Tainwala Ram, Sharma Yk
Department of Dermatology, Dr. D. Y. Patil Medical College, Pimpri, Pune, India.
Indian J Dermatol. 2011 May;56(3):259-61. doi: 10.4103/0019-5154.82476.
Dermatophytes can survive solely on outer cornified layers of the skin. The ability of certain fungi to adhere to particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. Natural infection is acquired by the deposition of viable arthrospores or hyphae on the surface of the susceptible individual. After the inoculation in the host skin, suitable conditions favor the infection to progress through the stages of adherence and penetration. Development of host response is mostly by a T-cell mediated response of delayed-type hypersensitivity. Antibody formation does not seem to be protective. Natural defenses against dermatophytes depend on both immunological and nonimmunological mechanisms.
皮肤癣菌仅能在皮肤的外层角质化层上存活。某些真菌附着于特定宿主的能力源于多种机制和宿主因素，包括适应人体的能力。自然感染是通过将有活力的关节孢子或菌丝沉积在易感个体的表面而获得的。在接种到宿主皮肤后，适宜的条件有利于感染经历黏附和穿透阶段而发展。宿主反应的发展主要是由迟发型超敏反应的T细胞介导的反应。抗体形成似乎没有保护作用。针对皮肤癣菌的天然防御依赖于免疫和非免疫机制。
