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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Trimarco B, Volpe M, Sacca L, Ricciardelli B, Ungaro B, Rengo F, Condorelli M

Clin Exp Pharmacol Physiol. 1982 Jan-Feb;9(1):95-100. doi: 10.1111/j.1440-1681.1982.tb00783.x.

This study was designed to compare the response of plasma arginine vasopressin (AVP) to head-up tilt in hypertensive patients and in normals. 2. As expected, plasma AVP showed a consistent increase (P less than 0.005) in normal subjects after tilt while plasma volume decreased significantly (P less than 0.02). On the contrary, in hypertensive patients, after tilt both plasma AVP (P less than 0.025) and plasma volume (P less than 0.05) decreased. 3. These findings, thus, indicate that essential hypertension is characterized by an inverted response of arginine vasopressin to postural change.

本研究旨在比较高血压患者和正常人血浆精氨酸加压素（AVP）对头高位倾斜的反应。2. 正如预期的那样，正常受试者在倾斜后血浆AVP呈现持续升高（P<0.005），而血浆容量显著下降（P<0.02）。相反，高血压患者在倾斜后血浆AVP（P<0.025）和血浆容量（P<0.05）均下降。3. 因此，这些发现表明原发性高血压的特征是精氨酸加压素对体位变化的反应倒置。

Trimarco B, Volpe M, Sacca L, Ricciardelli B, Ungaro B, Rengo F, Condorelli M

Clin Exp Pharmacol Physiol. 1982 Jan-Feb;9(1):95-100. doi: 10.1111/j.1440-1681.1982.tb00783.x.

This study was designed to compare the response of plasma arginine vasopressin (AVP) to head-up tilt in hypertensive patients and in normals. 2. As expected, plasma AVP showed a consistent increase (P less than 0.005) in normal subjects after tilt while plasma volume decreased significantly (P less than 0.02). On the contrary, in hypertensive patients, after tilt both plasma AVP (P less than 0.025) and plasma volume (P less than 0.05) decreased. 3. These findings, thus, indicate that essential hypertension is characterized by an inverted response of arginine vasopressin to postural change.

本研究旨在比较高血压患者和正常人血浆精氨酸加压素（AVP）对头高位倾斜的反应。2. 正如预期的那样，正常受试者在倾斜后血浆AVP呈现持续升高（P<0.005），而血浆容量显著下降（P<0.02）。相反，高血压患者在倾斜后血浆AVP（P<0.025）和血浆容量（P<0.05）均下降。3. 因此，这些发现表明原发性高血压的特征是精氨酸加压素对体位变化的反应倒置。