Bussien J P, Waeber B, Nussberger J, Hofbauer K G, Brunner H R
Arch Int Pharmacodyn Ther. 1986 Jul;282(1):130-9.
The effect of circulating arginine vasopressin (AVP) on blood pressure, heart rate and skin blood flow was investigated in 8 untreated patients with mild essential hypertension using a specific antagonist of the pressor effect of AVP. Skin blood flow was measured with a laser Doppler flowmeter and blood pressure with a Remler M2000 recorder. The study was carried out in double-blind fashion using a cross-over design. Each patient received at a 60 min interval the AVP-antagonist, d(CH2)5Tyr(Me) AVP, 5 micrograms/kg i.v., and its vehicle. The sequence of treatment phases was randomly allocated. Pretreatment plasma AVP levels averaged 1.1 +/- 0.2 pg/ml (mean +/- SEM). Neither the AVP-antagonist nor its vehicle had any effect on blood pressure, heart rate and skin blood flow as well as on plasma renin activity and plasma catecholamines. It is therefore concluded that circulating AVP does not contribute to the maintenance of blood pressure in patients with mild essential hypertension and normal plasma AVP levels.
使用精氨酸加压素（AVP）升压作用的特异性拮抗剂，对8例未经治疗的轻度原发性高血压患者循环中AVP对血压、心率和皮肤血流的影响进行了研究。用激光多普勒血流仪测量皮肤血流，用雷姆勒M2000记录仪测量血压。该研究采用交叉设计以双盲方式进行。每位患者每隔60分钟静脉注射5微克/千克的AVP拮抗剂d(CH2)5Tyr(Me) AVP及其赋形剂。治疗阶段的顺序是随机分配的。治疗前血浆AVP水平平均为1.1±0.2皮克/毫升（均值±标准误）。AVP拮抗剂及其赋形剂对血压、心率、皮肤血流以及血浆肾素活性和血浆儿茶酚胺均无影响。因此得出结论，在血浆AVP水平正常的轻度原发性高血压患者中，循环中的AVP对血压维持无作用。
