Carter D R
Crit Rev Biomed Eng. 1982;8(1):1-28.
Bone has the capacity to remodel in response to the mechanical demands which are made on it during in vivo activities. It has long been assumed that mathematical laws exist which can describe the relationship between bone stress or strain histories and the remodeling activity of the bone tissue. Despite extensive research into bone stress/remodeling relationships, these mathematical laws have not yet been formulated. Research into this important area of bone physiology will be reviewed and the current state of knowledge assessed. Promising new directions in this research area will be discussed.
骨骼具有根据体内活动期间对其施加的机械需求进行重塑的能力。长期以来，人们一直认为存在能够描述骨应力或应变历史与骨组织重塑活动之间关系的数学定律。尽管对骨应力/重塑关系进行了广泛研究，但这些数学定律尚未形成。本文将综述骨生理学这一重要领域的研究，并评估当前的知识状态。还将讨论该研究领域有前景的新方向。
