Chalmers R J, Bennie E H
Psychol Med. 1978 Aug;8(3):483-6. doi: 10.1017/s0033291700016160.
The effect of fluphenazine on basal human prolactin (hPRL) concentrations was studied in 10 male schizophrenics who had received fluphenazine treatment for at least 6 months, in 10 male alcoholics before and during the first week of fluphenazine treatment and in 8 alcoholics at daily intervals before and after treatment. The results were compared with basal hPRL concentrations in 17 healthy male controls. Investigations involved giving fluphenazine (Modecate)by intramuscular injection and taking blood samples at appropriate intervals by venepuncture. Basal hPRL concentrations were significantly increased in the schizophrenics. The alcoholics showed a significant rise in hPRL concentrations after fluphenazine but there was considerable variation in hPRL levels between individual patients. Most patients showed marked elevation of daily hPRL levels with peak concentrations occurring 5--6 days after the injection. The results demonstrate that fluphenazine elevates basal hPRL levels and the variation between levels of individual patients merits further investigation.
在10名接受氟奋乃静治疗至少6个月的男性精神分裂症患者、10名男性酗酒者在氟奋乃静治疗前及治疗第一周期间以及8名酗酒者在治疗前后每天进行间隔检测，研究了氟奋乃静对人基础催乳素（hPRL）浓度的影响。将结果与17名健康男性对照者的基础hPRL浓度进行比较。研究包括通过肌肉注射给予氟奋乃静（Modecate），并通过静脉穿刺在适当间隔采集血样。精神分裂症患者的基础hPRL浓度显著升高。酗酒者在使用氟奋乃静后hPRL浓度显著升高，但个体患者之间的hPRL水平存在相当大的差异。大多数患者每日hPRL水平显著升高，注射后5 - 6天出现峰值浓度。结果表明，氟奋乃静可提高基础hPRL水平，个体患者之间水平的差异值得进一步研究。
