Chalmers R J, Bennie E H, Johnson R H
Clin Endocrinol (Oxf). 1978 Jan;8(1):75-9. doi: 10.1111/j.1365-2265.1978.tb01352.x.
The growth hormone (hGH) and prolactin (hPRL) response to insulin induced hypoglycaemia was studied in six alcoholics on two occasions before and after treatment with a single intramuscular injection of fluphenazine (Modecate). On both occasions blood samples were taken at intervals before and after the intravenous injection of soluble insulin (0.1 u/kg body weight). The patients were investigated on the first occasion, 2-7 days after cessation of drinking and they all demonstrated an adequate hGH response. They then received an injection of fluphenazine (Modecate 12.5 mg) and were reinvestigated 1 week later. The hGH response to hypoglycaemia was significantly impaired after treatment with fluphenazine. Basal hPRL concentrations were significantly increased and increased concentrations of hPRL in response to hypoglycaemia occurred after treatment. We conclude that a single injection of fluphenazine (Modecate 12.5 mg) has a marked effect on hypothalamic-pituitary mechanisms controlling hGH and hPRL release.
在六名酗酒者身上，研究了生长激素（hGH）和催乳素（hPRL）对胰岛素诱导的低血糖的反应，研究分两次进行，分别在单次肌肉注射氟奋乃静（Modecate）治疗前后。两次实验中，均在静脉注射可溶性胰岛素（0.1 u/kg体重）前后的不同时间点采集血样。第一次调查时，患者在戒酒2至7天后接受研究，他们都表现出足够的hGH反应。然后他们接受了一次氟奋乃静注射（Modecate 12.5 mg），并在1周后再次接受调查。氟奋乃静治疗后，hGH对低血糖的反应明显受损。基础hPRL浓度显著升高，治疗后hPRL对低血糖的反应浓度也升高。我们得出结论，单次注射氟奋乃静（Modecate 12.5 mg）对控制hGH和hPRL释放的下丘脑-垂体机制有显著影响。
