慢性酒精中毒患者的血清多巴胺-β-羟化酶

Serum dopamine-beta-hydroxylase in chronic alcoholism.

作者信息

Sullivan J L, Stanfield C N, Schanberg S, Cavenar J

出版信息

Psychol Med. 1978 Aug;8(3):505-8. doi: 10.1017/s0033291700016214.

Abstract

Previous reports suggest that high serum dopamine-beta-hydroxylase (DBH) activity may be associated with vulnerability to alcoholism. However, there are also contradictory studies in the literature. Therefore we measured serum DBH in chronic alcoholics followed for 12 months in a treatment programme after psychiatric hospitalization for acute alcoholism. Mean serum DBH activity in the alcoholics was unchanged from controls at 3 months, 6 months and 12 months following hospital discharge. These data imply that serum DBH activity does not provide a useful metabolic screen for vulnerability to chronic alcoholism. However, prospective studies of patients at high risk to develop alcoholism will be helpful in further clarification of this issue.

摘要

先前的报告表明，血清多巴胺-β-羟化酶（DBH）活性较高可能与酒精成瘾易感性有关。然而，文献中也存在相互矛盾的研究。因此，我们对因急性酒精中毒而接受精神科住院治疗的慢性酒精中毒患者进行了为期12个月的治疗方案随访，并测量了他们的血清DBH。出院后3个月、6个月和12个月时，酒精中毒患者的平均血清DBH活性与对照组相比没有变化。这些数据表明，血清DBH活性并不能为慢性酒精中毒易感性提供有用的代谢筛查。然而，对有酒精成瘾高风险患者的前瞻性研究将有助于进一步阐明这个问题。