T淋巴细胞克隆上胰岛素受体的诱导表达。
Inducible expression of insulin receptors on T lymphocyte clones.
作者信息
Braciale V L, Gavin J R, Braciale T J
出版信息
J Exp Med. 1982 Aug 1;156(2):664-9. doi: 10.1084/jem.156.2.664.
Abstract
This study demonstrates that the insulin receptors are expressed on the surface of some T cell clones after specific antigenic stimulation. The insulin receptors on these lymphocytes are physicochemically similar to insulin receptors present on cells which express the receptors constitutively (adipocytes, hepatocytes, etc.). The kinetics of expression of insulin receptors on cloned, noncytotoxic T cells after specific antigenic stimulation closely parallels that of [3H]thymidine incorporation in such cultures.
摘要
本研究表明，在特定抗原刺激后，胰岛素受体在一些T细胞克隆的表面表达。这些淋巴细胞上的胰岛素受体在物理化学性质上与组成性表达受体的细胞（脂肪细胞、肝细胞等）上存在的胰岛素受体相似。特定抗原刺激后，克隆的非细胞毒性T细胞上胰岛素受体的表达动力学与此类培养物中[3H]胸腺嘧啶核苷掺入的动力学密切平行。
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