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1
Escherichia coli mutant which restricts T7 bacteriophage has an altered RNA polymerase.限制T7噬菌体的大肠杆菌突变体具有改变的RNA聚合酶。
J Virol. 1982 Jun;42(3):1123-6. doi: 10.1128/JVI.42.3.1123-1126.1982.
2
Characterization of the defects in bacteriophage T7 DNA synthesis during growth in the Escherichia coli mutant tsnB.噬菌体T7在大肠杆菌突变体tsnB中生长期间DNA合成缺陷的特征分析
J Virol. 1980 Feb;33(2):780-8. doi: 10.1128/JVI.33.2.780-788.1980.
3
Accumulation of bacteriophage T7 head-related particles in an Escherichia coli mutant.噬菌体T7头部相关颗粒在大肠杆菌突变体中的积累。
J Virol. 1979 Jul;31(1):209-19. doi: 10.1128/JVI.31.1.209-219.1979.
4
Genetic analysis of two bacterial RNA polymerase mutants that inhibit the growth of bacteriophage T7.对两种抑制噬菌体T7生长的细菌RNA聚合酶突变体的遗传分析。
Mol Gen Genet. 1982;188(2):211-8. doi: 10.1007/BF00332677.
5
Binding of Escherichia coli RNA polymerase holoenzyme to bacteriophage T7 DNA. Measurements of binding at bacteriophage T7 promoter A1 using a template competition assay.大肠杆菌RNA聚合酶全酶与噬菌体T7 DNA的结合。使用模板竞争分析法对噬菌体T7启动子A1处的结合进行测量。
J Mol Biol. 1982 Feb 15;155(1):1-29. doi: 10.1016/0022-2836(82)90489-2.
6
Rescue of abortive T7 gene 2 mutant phage infection by rifampin.利福平对流产型T7基因2突变噬菌体感染的挽救作用
J Virol. 1980 May;34(2):438-45. doi: 10.1128/JVI.34.2.438-445.1980.
7
Binding of Escherichia coli RNA polymerase holoenzyme to bacteriophage T7 DNA. Measurements of the rate of open complex formation at T7 promoter A.大肠杆菌RNA聚合酶全酶与噬菌体T7 DNA的结合。T7启动子A处开放复合物形成速率的测定。
J Mol Biol. 1982 Feb 15;155(1):31-51. doi: 10.1016/0022-2836(82)90490-9.
8
Altered transcriptional termination in a rifampicin-resistant mutant of Escherichia coli which inhibits the growth of bacteriophage T7.大肠杆菌利福平抗性突变体中改变的转录终止，该突变体抑制噬菌体T7的生长。
Mol Gen Genet. 1981;183(1):181-6. doi: 10.1007/BF00270159.
9
Gene 2 protein of bacteriophage T7: purification and requirement for packaging of T7 DNA in vitro.噬菌体T7的基因2蛋白：体外纯化及T7 DNA包装的需求
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4852-6. doi: 10.1073/pnas.76.10.4852.
10
"Host shutoff" function of bacteriophage T7: involvement of T7 gene 2 and gene 0.7 in the inactivation of Escherichia coli RNA polymerase.噬菌体T7的“宿主关闭”功能：T7基因2和基因0.7参与大肠杆菌RNA聚合酶的失活
J Virol. 1977 Dec;24(3):736-45. doi: 10.1128/JVI.24.3.736-745.1977.

引用本文的文献

1
Genetic analysis of two bacterial RNA polymerase mutants that inhibit the growth of bacteriophage T7.对两种抑制噬菌体T7生长的细菌RNA聚合酶突变体的遗传分析。
Mol Gen Genet. 1982;188(2):211-8. doi: 10.1007/BF00332677.

本文引用的文献

1
Nucleotide sequence from the genetic left end of bacteriophage T7 DNA to the beginning of gene 4.从噬菌体T7 DNA的遗传左端到基因4起始处的核苷酸序列。
J Mol Biol. 1981 Jun 5;148(4):303-30. doi: 10.1016/0022-2836(81)90178-9.
2
Characterization of the defects in bacteriophage T7 DNA synthesis during growth in the Escherichia coli mutant tsnB.噬菌体T7在大肠杆菌突变体tsnB中生长期间DNA合成缺陷的特征分析
J Virol. 1980 Feb;33(2):780-8. doi: 10.1128/JVI.33.2.780-788.1980.
3
Rescue of abortive T7 gene 2 mutant phage infection by rifampin.利福平对流产型T7基因2突变噬菌体感染的挽救作用
J Virol. 1980 May;34(2):438-45. doi: 10.1128/JVI.34.2.438-445.1980.
4
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
5
The genetics and physiology of bacteriophage T7.噬菌体T7的遗传学与生理学
Virology. 1969 Nov;39(3):562-74. doi: 10.1016/0042-6822(69)90104-4.
6
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.通过SDS-聚丙烯酰胺凝胶电泳对多肽链进行分子量估计
Biochem Biophys Res Commun. 1967 Sep 7;28(5):815-20. doi: 10.1016/0006-291x(67)90391-9.
7
Genetic analysis of non-essential bacteriophage T7 genes.非必需噬菌体T7基因的遗传分析。
J Mol Biol. 1973 Sep 15;79(2):227-36. doi: 10.1016/0022-2836(73)90002-8.
8
Reference mutations for the beta subunit of RNA polymerase.RNA聚合酶β亚基的参考突变
Mol Gen Genet. 1974 Jun 27;130(4):315-20. doi: 10.1007/BF00333870.
9
Isolation and characterization of prototrophic mutants of Escherichia coli unable to support the intracellular growth of T7.无法支持T7在细胞内生长的大肠杆菌原养型突变体的分离与鉴定
J Virol. 1974 Sep;14(3):509-16. doi: 10.1128/JVI.14.3.509-516.1974.
10
Transcription of the early region of bacteriophage T7: selective initiation with dinucleotides.噬菌体T7早期区域的转录：二核苷酸的选择性起始
J Mol Biol. 1973 Jun 25;77(2):255-77. doi: 10.1016/0022-2836(73)90335-5.

限制T7噬菌体的大肠杆菌突变体具有改变的RNA聚合酶。

Escherichia coli mutant which restricts T7 bacteriophage has an altered RNA polymerase.

作者信息

Shanblatt S H, Nakada D

出版信息

J Virol. 1982 Jun;42(3):1123-6. doi: 10.1128/JVI.42.3.1123-1126.1982.

DOI:10.1128/JVI.42.3.1123-1126.1982
PMID:7047764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256954/
Abstract

We have previously described an Escherichia coli K-12 mutant, Y49, which restricts the growth of bacteriophage T7 and causes the accumulation of short DNA molecules and head-related particles during infection. We now show that the basis for these effects is the inability of the T7 gene 2 product to inactivate the Y49 RNA polymerase during infection, similar to what has been shown by DeWyngaert and Hinkle (J. Biol. Chem. 254:11247--11253, 1979) for the BR3 and tsnB strains of E. coli.

摘要

我们之前描述过一株大肠杆菌K-12突变体Y49，它能限制噬菌体T7的生长，并在感染过程中导致短DNA分子和头部相关颗粒的积累。我们现在表明，这些效应的基础是T7基因2产物在感染过程中无法使Y49 RNA聚合酶失活，这与DeWyngaert和Hinkle（《生物化学杂志》254:11247-11253, 1979）对大肠杆菌BR3和tsnB菌株所显示的情况类似。