McDonald M, Ward P, Harvey K
Med J Aust. 1982 May 29;1(11):462-4.
Methicillin-resistant Staphylococcus aureus was thought to be the cause of 10 cases of antibiotic-associated diarrhoea observed over a 12-month period at The Royal Melbourne Hospital. Each patient had significant underlying disease, and all had been treated with multiple, broad-spectrum antibiotic agents. The diagnosis was made on the distinctive Gram-stain appearance of faecal smears, the heavy predominant growth of methicillin-resistant Staph. aureus from stool cultures, and the absence of other bowel pathogens, including toxigenic Clostridium difficile. Diarrhoea usually responded to treatment with vancomycin or bacitracin, and, in patients whose condition improved, the stools cleared of staphylococci. Patients with staphylococcal diarrhoea present a significant crossinfection risk, and early diagnosis, treatment, and isolation are essential.
耐甲氧西林金黄色葡萄球菌被认为是皇家墨尔本医院在12个月期间观察到的10例抗生素相关性腹泻的病因。每位患者都有严重的基础疾病，并且都接受过多种广谱抗生素治疗。诊断依据粪便涂片独特的革兰氏染色外观、粪便培养中耐甲氧西林金黄色葡萄球菌的大量优势生长以及其他肠道病原体（包括产毒素艰难梭菌）的缺失。腹泻通常对万古霉素或杆菌肽治疗有反应，病情好转的患者粪便中的葡萄球菌会清除。金黄色葡萄球菌性腹泻患者存在重大的交叉感染风险，早期诊断、治疗和隔离至关重要。
