Albert D J, Walsh M L
Neurosci Biobehav Rev. 1982 Summer;6(2):125-43. doi: 10.1016/0149-7634(82)90051-3.
Neural regions which exercise an inhibitory influence on agonistic behavior are identified by the enhancement of agonistic behavior that follows their removal. The specific kinds of agonistic behaviors altered by each region are then examined. Increased reactivity to the experimenter and enhanced shock-induced fighting are produced by lesions of the region ventral to the anterior septum, the lateral septum, the medial hypothalamus, and the dorsal and median raphe nuclei. It is argued that the increased reactivity and shock-induced fighting correspond to an enhancement of defensive behavior. Mouse killing is induced by lesions of the anterior olfactory nucleus, the region ventral to the anterior septum, the lateral septum, the medial hypothalamus, the dorsal and median raphe nuclei, and the medial amygdala. Because the lesion-induced mouse killing is similar to that emitted by spontaneous mouse killers, it is argued that these regions normally exert an inhibitory control over predatory killing. The available evidence on social attack behavior has not convincingly identified regions exerting an inhibitory control over this dimension of behavior. Our conclusion is that separate brain systems exert an inhibitory control over defensive behavior, predatory killing, and social attack behavior. To a substantial extent, the regions modulating these behaviors appear to act independently of one another. The only neurotransmitter that is clearly active in these inhibitory systems is serotonin, and has only been directly implicated in the control of mouse killing by neurons originating in the dorsal and median raphe nuclei.
通过去除对攻击行为具有抑制作用的神经区域后攻击行为的增强来确定这些区域。然后检查每个区域改变的特定类型的攻击行为。前隔腹侧、外侧隔、内侧下丘脑以及背侧和中缝核的损伤会导致对实验者的反应性增加以及电击诱导的打斗增强。有人认为，反应性增加和电击诱导的打斗对应于防御行为的增强。前嗅核、前隔腹侧区域、外侧隔、内侧下丘脑、背侧和中缝核以及内侧杏仁核的损伤会诱发小鼠杀戮行为。由于损伤诱导的小鼠杀戮行为与自发小鼠杀手的行为相似，因此有人认为这些区域通常对掠食性杀戮施加抑制控制。关于社会攻击行为的现有证据尚未令人信服地确定对这一行为维度施加抑制控制的区域。我们的结论是，不同的脑系统对防御行为、掠食性杀戮和社会攻击行为施加抑制控制。在很大程度上，调节这些行为的区域似乎彼此独立起作用。在这些抑制系统中明显活跃的唯一神经递质是血清素，并且仅直接涉及起源于背侧和中缝核的神经元对小鼠杀戮的控制。
