Albert D J, Walsh M L, Ryan J, Siemens Y
Physiol Behav. 1982 Jun;28(6):1117-20. doi: 10.1016/0031-9384(82)90186-x.
Adult male rats were either gentled or not gentled 10 min each day for 5 days and then subjected to lesions of the lateral septum, the medial accumbens, the medial hypothalamus, or were given sham lesions. Mouse killing was tested in the living cage on Days 2, 7, and 14 postoperatively while reactivity to the experimenter was tested on Days 3, 8, and 15. The frequency of killing in the gentled groups was always significantly higher than that of the gentled sham-lesion controls, but the frequency of killing by the nongentled groups was seldom significantly higher than that of the nongentled sham-lesioned controls. Gentling caused a slight enhancement of killing in the lesioned animals and a slight attenuation of killing in the sham lesioned animals. Preoperative gentling attenuated reactivity to the experimenter in animals with lesions of the lateral septum but not in those with lesions of the medial accumbens nucleus or the medial hypothalamus. The observation that preoperative gentling tends to increase mouse killing confirms previous observations. The finding that preoperative gentling attenuates reactivity following septal but not medial accumbens or medial hypothalamic lesions suggests that these structures subserve different functions in the inhibitory modulation of defensive behavior.
成年雄性大鼠每天接受10分钟的安抚或不接受安抚，持续5天，然后接受外侧隔区、伏隔核内侧、下丘脑内侧的损伤，或进行假损伤。术后第2天、第7天和第14天在饲养笼中测试杀鼠情况，术后第3天、第8天和第15天测试对实验者的反应性。接受安抚组的杀鼠频率总是显著高于接受安抚的假损伤对照组，但未接受安抚组的杀鼠频率很少显著高于未接受安抚的假损伤对照组。安抚使损伤动物的杀鼠行为略有增强，使假损伤动物的杀鼠行为略有减弱。术前安抚减弱了外侧隔区损伤动物对实验者的反应性，但对伏隔核内侧或下丘脑内侧损伤的动物没有影响。术前安抚倾向于增加杀鼠行为这一观察结果证实了先前的观察。术前安抚在隔区损伤后减弱反应性，但在伏隔核内侧或下丘脑内侧损伤后没有减弱反应性，这一发现表明这些结构在防御行为的抑制调节中发挥不同的功能。
