Stormo G D, Schneider T D, Gold L M
Nucleic Acids Res. 1982 May 11;10(9):2971-96. doi: 10.1093/nar/10.9.2971.
We characterize the Shine and Dalgarno sequence of 124 known gene beginnings. This information is used to make "rules" which help distinguish gene beginning from other sites in a library of over 78,000 bases of mRNA. Gene beginnings are found to have information besides the initiation codon and Shine and Dalgarno sequence which can be used to make better "rules".
我们对124个已知基因起始位点的夏因-达尔加诺序列进行了特征描述。这些信息被用于制定“规则”,以帮助在一个超过78000个碱基的mRNA文库中区分基因起始位点和其他位点。研究发现,基因起始位点除了起始密码子以及夏因-达尔加诺序列外,还具有可用于制定更优“规则”的信息。