[Chronic action of the fat-mobilizing fragment of human somatotropin on the fat content of fat depots and the plasma glucose level in rabbits].

The effect was studied of synthetic tetradecapeptide-the fat-mobilizing human somatotropin fragment 31-34--on the fat content in fat depot and glucode concentration in the rabbit blood plasma and urine. A marked decrease in subcutaneous (the nape region), perirenal, mesenteric and epididimal fat content, accompanied by partial replacement of the fatty tissue by the connective one, was seen 3 to 4 weeks after tetradecapeptide injection to rabbits. Peptide effect manifested itself only under condition of the inadequate diet and was especially pronounced in young animals. Clucosuria and hyperglycemia were not observed after chronic tetradecapeptide injection. Tetradecapeptide did not exert an evident hyperglycemic or insulinogenous effect and did not produce a marked glucose tolerance fall after short administration to rabbits and during the glucose tolerance test in rats.