Potter D E, Morris J W, Rowland J M
Pharmacology. 1982;24(5):314-20. doi: 10.1159/000137612.
It has been postulated that ethanol-induced changes in carbohydrate hemeostasis are mediated in part by alterations in pancreatic endocrine function. In this study ethanol (40, 120 and 240 mg/dl) produced dose-related suppression of immunoreactive insulin (IRI) release from isolated rat islets perifused with glucose and theophylline. Acetaldehyde inhibited IRI release at a concentration (39 mg/dl) much higher than can be achieved in vivo. A high concentration (29 mg/dl) of acetate did not influence IRI release. These results suggest that the ability of ethanol to inhibit IRI release resides principally in the parent compound and not its metabolites.
据推测，乙醇诱导的碳水化合物稳态变化部分是由胰腺内分泌功能改变介导的。在本研究中，乙醇（40、120和240mg/dl）对灌注葡萄糖和茶碱的离体大鼠胰岛释放免疫反应性胰岛素（IRI）产生了剂量相关的抑制作用。乙醛在远高于体内可达到的浓度（39mg/dl）时抑制IRI释放。高浓度（29mg/dl）的乙酸盐不影响IRI释放。这些结果表明，乙醇抑制IRI释放的能力主要在于母体化合物而非其代谢产物。
