Nilsson N O, Belfrage P
J Lipid Res. 1978 Aug;19(6):737-411.
The effects of different concentrations of acetate, acetaldehyde, and ethanol, alone or in combination, on the lipolysis rate, measured as glycerol release, were studied in isolated adipocytes from fed or fasted rats, in the basal state and at various levels of norepinephrine stimulation. Acetate inhibited the glycerol release in a dose-dependent manner (congruent to 10% inhibition at 2 mM, 25--70% at 10 mM) with the most marked effects at low to moderate norepinephrine concentratione and at maximal (100 ng/ml) hormone stimulation. Ethanol, up to 100 mM concentration, had no effect on the lipolysis rate. Acetaldehyde, up to 1 mM concentration, had no reproducible effect. Ethanol, acetaldehyde, and acetate in combination inhibited glycerol release to an extent similar to that of acetate alone.
研究了不同浓度的乙酸盐、乙醛和乙醇单独或联合作用，对以甘油释放量衡量的脂肪分解速率的影响，实验对象是取自喂食或禁食大鼠的分离脂肪细胞，处于基础状态以及不同去甲肾上腺素刺激水平下。乙酸盐以剂量依赖方式抑制甘油释放（2 mM时约10%抑制，10 mM时25%-70%抑制），在低至中等去甲肾上腺素浓度以及最大（100 ng/ml）激素刺激时作用最显著。高达100 mM浓度的乙醇对脂肪分解速率无影响。高达1 mM浓度的乙醛无重复性作用。乙醇、乙醛和乙酸盐联合使用时对甘油释放的抑制程度与单独使用乙酸盐时相似。
