Kraly F S, Miller L A
Physiol Behav. 1982 May;28(5):841-6. doi: 10.1016/0031-9384(82)90201-3.
While transection of either the anterior (including hepatic) or posterior (including coeliac) vagal trunk failed to alter drinking in response to subcutaneous histamine (0.312--20 mg/kg), selective gastric vagotomy severely attenuated drinking after systemic histamine (1.25--40 mg/kg) in male Sprague-Dawley rats. The dose-response curve for rats with gastric vagotomy was shifted to the right. Vagotomy increased the threshold dose nearly tenfold and more than doubled the ED50. Because the effect of vagotomy on histamine-elicited drinking was not mimicked by cholinergic blockade of vagal efferents using atropine methyl nitrate (10 mg/kg), these results demonstrate that gastric vagal afferents are necessary for a normal drinking response to systemic histamine. When gastric vagotomy was combined with intragastric SQ14,225 (to inhibit the conversion of peripheral angiotensin I to angiotensin II) drinking after systemic histamine was abolished. These results suggest that gastric vagal afferents and angiotensin II are necessary for systemic histamine to elicit drinking in the rat.
虽然切断前迷走神经干（包括肝支）或后迷走神经干（包括腹腔支）均未能改变雄性Sprague-Dawley大鼠对皮下注射组胺（0.312 - 20毫克/千克）的饮水反应，但选择性胃迷走神经切断术显著减弱了大鼠在全身注射组胺（1.25 - 40毫克/千克）后的饮水。胃迷走神经切断术大鼠的剂量-反应曲线向右移动。迷走神经切断术使阈剂量增加了近十倍，使半数有效剂量增加了一倍多。由于使用硝酸甲基阿托品（10毫克/千克）对迷走神经传出纤维进行胆碱能阻断并不能模拟迷走神经切断术对组胺诱发饮水的影响，这些结果表明胃迷走神经传入纤维对于大鼠对全身组胺的正常饮水反应是必需的。当胃迷走神经切断术与胃内注射SQ14,225（抑制外周血管紧张素I转化为血管紧张素II）联合应用时，全身注射组胺后的饮水被消除。这些结果表明胃迷走神经传入纤维和血管紧张素II对于全身组胺在大鼠中诱发饮水是必需的。
