Su C T, Im M J, Hoopes J E
Plast Reconstr Surg. 1982 Aug;70(2):202-5. doi: 10.1097/00006534-198208000-00014.
Neurovascular island skin flaps were elevated in the right groin area of Sprague-Dawley female rats weighing from 200 to 250 gm. Survival rates of the flaps were determined following venous and/or arterial occlusions of the femoral vessels. All the flaps exhibited an 80 percent decrease in tissue glucose content and an increase in tissue lactate content 4 to 7 times normal during venous and/or arterial occlusion. In the groups occluded for 8 hours, venous occlusion resulted in loss of all the flaps; arterial occlusion yielded survival of 70 percent of the flaps; and occlusion of both vessels yielded survival of 30 percent of the flaps. The results indicate that venous occlusion is more detrimental to flap survival than arterial occlusion. Surviving flaps exhibited a glucose content of 3.5 times normal, and dying flaps exhibited a glucose content of 20 percent of normal and a lactate content of 5.1 times normal. The ratio of tissue lactate to glucose may serve as an index for tissue viability: normal flaps, 0.3, surviving flaps, 1.2, and dying flaps, 7.5.
在体重200至250克的雌性Sprague-Dawley大鼠的右腹股沟区域掀起神经血管岛状皮瓣。在股血管静脉和/或动脉闭塞后测定皮瓣的存活率。在静脉和/或动脉闭塞期间，所有皮瓣的组织葡萄糖含量均降低80%，组织乳酸含量增加至正常水平的4至7倍。在闭塞8小时的组中，静脉闭塞导致所有皮瓣坏死；动脉闭塞使70%的皮瓣存活；双侧血管闭塞使30%的皮瓣存活。结果表明，静脉闭塞对皮瓣存活的损害比动脉闭塞更大。存活的皮瓣葡萄糖含量为正常水平的3.5倍，坏死的皮瓣葡萄糖含量为正常水平的20%，乳酸含量为正常水平的5.1倍。组织乳酸与葡萄糖的比值可作为组织活力的指标：正常皮瓣为0.3，存活皮瓣为1.2，坏死皮瓣为7.5。
