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阿昔洛韦与阿糖腺苷治疗疱疹性角膜溃疡的双盲临床试验。

Double-blind clinical trial of acyclovir and adenine arabinoside in herpetic corneal ulceration.

作者信息

Young B, Patterson A, Ravenscroft T

出版信息

Am J Med. 1982 Jul 20;73(1A):311-2. doi: 10.1016/0002-9343(82)90113-9.

DOI:10.1016/0002-9343(82)90113-9
PMID:7048918
Abstract

The results of a double-blind clinical trials of acyclovir and adenosine arabinoside (ara-A) in 93 patients with herpetic keratitis demonstrated a significantly faster healing rate for acyclovir (p less than 0.01). Ulcers in 45 (94 percent) of acyclovir-treated patients and 37 (82 percent) of ara-A-treated patients healed within 14 days. No serious side effects were observed.

摘要

对93例疱疹性角膜炎患者进行的阿昔洛韦和阿糖腺苷(ara - A)双盲临床试验结果表明,阿昔洛韦的愈合速度明显更快(p小于0.01)。在接受阿昔洛韦治疗的45例患者(94%)和接受阿糖腺苷治疗的37例患者(82%)中,溃疡在14天内愈合。未观察到严重副作用。

相似文献

1
Double-blind clinical trial of acyclovir and adenine arabinoside in herpetic corneal ulceration.阿昔洛韦与阿糖腺苷治疗疱疹性角膜溃疡的双盲临床试验。
Am J Med. 1982 Jul 20;73(1A):311-2. doi: 10.1016/0002-9343(82)90113-9.
2
A randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration.阿昔洛韦(无环鸟苷)与阿糖腺苷治疗单纯疱疹性角膜溃疡的随机双盲临床试验
Br J Ophthalmol. 1982 Jun;66(6):361-3. doi: 10.1136/bjo.66.6.361.
3
Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers.阿昔洛韦与阿糖腺苷治疗单纯疱疹性角膜溃疡的对比试验
Br J Ophthalmol. 1981 Sep;65(9):610-3. doi: 10.1136/bjo.65.9.610.
4
Randomised double-blind trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex amoeboid corneal ulceration.阿昔洛韦(无环鸟苷)与阿糖腺苷治疗单纯疱疹性阿米巴样角膜溃疡的随机双盲试验
Br J Ophthalmol. 1985 Nov;69(11):847-50. doi: 10.1136/bjo.69.11.847.
5
Acyclovir and vidarabine for the treatment of herpes simplex keratitis.阿昔洛韦和阿糖腺苷治疗单纯疱疹性角膜炎。
Am J Med. 1982 Jul 20;73(1A):281-5. doi: 10.1016/0002-9343(82)90106-1.
6
A double-blind comparative trial of acyclovir and adenine arabinoside in combination with dilute betamethasone in the management of herpetic disciform keratitis.阿昔洛韦与阿糖腺苷联合稀释倍他米松治疗盘状疱疹性角膜炎的双盲对照试验。
Curr Eye Res. 1987 Jan;6(1):221-4. doi: 10.3109/02713688709020094.
7
Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis.阿昔洛韦和阿糖腺苷治疗单纯疱疹性溃疡性角膜炎。
Am J Ophthalmol. 1981 Dec;92(6):829-35. doi: 10.1016/s0002-9394(14)75638-7.
8
Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis.阿昔洛韦和三氟胸苷治疗疱疹性角膜炎的多中心试验。
Am J Med. 1982 Jul 20;73(1A):305-6. doi: 10.1016/0002-9343(82)90111-5.
9
Comparison of the efficacy and toxicity of acyclovir and of adenine arabinoside when combined with dilute betamethasone in herpetic disciform keratitis: preliminary results of a double-blind trial.阿昔洛韦与阿糖腺苷联合稀释倍他米松治疗盘状疱疹性角膜炎的疗效与毒性比较:一项双盲试验的初步结果
Trans Ophthalmol Soc U K (1962). 1983;103 ( Pt 6):597-9.
10
[Comparison of the effectiveness of acyclovir and vidarabine in superficial herpes keratitis].[阿昔洛韦与阿糖腺苷治疗浅层疱疹性角膜炎的疗效比较]
Klin Monbl Augenheilkd. 1987 Jul;191(1):30-2.

引用本文的文献

1
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的抗病毒治疗及其他治疗干预措施。
Cochrane Database Syst Rev. 2015 Jan 9;1(1):CD002898. doi: 10.1002/14651858.CD002898.pub5.
2
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.单纯疱疹病毒性上皮性角膜炎的抗病毒治疗及其他治疗干预措施。
Cochrane Database Syst Rev. 2010 Dec 8(12):CD002898. doi: 10.1002/14651858.CD002898.pub4.
3
Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.
阿昔洛韦。对其药效学特性及治疗效果的综述。
Drugs. 1983 Nov;26(5):378-438. doi: 10.2165/00003495-198326050-00002.