一些前列腺素E1和ω-高前列腺素E1酯的制备及其对大鼠血小板聚集的抑制特性

Preparation of some prostaglandin E1 and omega-homo-prostaglandin E1 esters and their inhibiting properties on rat blood platelet aggregation.

作者信息

van der Wolf L, Kloeze J, Pabon H J, van Dorp D A

出版信息

Prostaglandins. 1978 May;15(5):795-801. doi: 10.1016/0090-6980(78)90145-4.

Abstract

Various esters of omega-homo-prostaglandin E1 and prostaglandin E1 were prepared in a yield of 28-55% to investigate their effect on ADP-induced aggregation of rat blood platelets. The biopotency of the omega-homo-PGE1-esters is about four times higher than that of the corresponding PGE1-esters. Furthermore, the biopotency of aliphatic esters decreases with increasing chain length of the ester group.

摘要

制备了多种ω-高前列腺素E1和前列腺素E1的酯，产率为28 - 55%，以研究它们对ADP诱导的大鼠血小板聚集的影响。ω-高前列腺素E1酯的生物活性比相应的前列腺素E1酯高约四倍。此外，脂肪族酯的生物活性随酯基链长的增加而降低。