11-脱氧-二氢-前列腺素E1的反式氢化茚核类似物的合成。
Synthesis of a trans-hydrindane nuclear analog of 11-desoxy-dihydro-prostaglandin E1.
作者信息
Anzeveno P B
出版信息
Prostaglandins. 1978 Jul;16(1):79-83. doi: 10.1016/0090-6980(78)90203-4.
PMID:704926
Abstract
Stereospecific synthesis of trans-hydrindanone 2a, a bicyclic analog of prostaglandin E1, via the trans- hydrindane beta-keto ester 8, is described. When tested in the guinea pig, 2a exhibited no effects on blood pressure and no broncho-constriction or dilation activity. Additionally, 2a failed to inhibit both ADP and collagen induced blood platelet aggregation.
摘要
描述了通过反式氢化茚β-酮酯8立体定向合成反式氢化茚酮2a（前列腺素E1的双环类似物）的方法。在豚鼠身上进行测试时，2a对血压没有影响，也没有支气管收缩或扩张活性。此外，2a未能抑制ADP和胶原诱导的血小板聚集。
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