Baker C J, Kasper D L
J Infect Dis. 1977 Aug;136 Suppl:S98-104. doi: 10.1093/infdis/136.supplement.s98.
Purified polysaccharide from type III group B Streptococcus contains both a type III-specific determinant and another determinant that is common to strains of serotypes other than type III. The polysaccharide contains sialic acid, galactose, heptose, glucose, glucosamine, and mannose. Serum antibody to this antigen was measured by means of a radioactive antigen-binding assay. Sera from 36 (67.9%) of 53 women with healthy newoborns contained antibody, a prevalence significantly different from that in sera from 15 women (13.3%) whose neonates developed septicemia or meningitis due to type III group B Streptococcus. Complete concordance for presence or absence of anticapsular antibody in sera from 14 women at delivery and in their neonates' cord sera was demonstrated; this concordance indicates transplacental transfer of antibody. Sera from each of four adults with invasive infection who were studied during convalescence contained antibody to the capsular polysaccharide of type III group B Streptococcus. In contrast, antibody was absent from 10 infants who had recovered from bacteremia, septicemia, and/or meningitis due to type III group B Streptococcus.
来自B族链球菌III型的纯化多糖含有III型特异性决定簇和另一种决定簇，该决定簇是III型以外血清型菌株所共有的。该多糖含有唾液酸、半乳糖、庚糖、葡萄糖、氨基葡萄糖和甘露糖。通过放射性抗原结合试验检测针对该抗原的血清抗体。53名健康新生儿母亲中的36名（67.9%）血清中含有抗体，这一患病率与15名新生儿因B族链球菌III型发生败血症或脑膜炎的母亲血清中的患病率（13.3%）有显著差异。14名妇女分娩时血清及其新生儿脐带血清中抗荚膜抗体的存在与否完全一致；这种一致性表明抗体可经胎盘转移。在恢复期对4名患有侵袭性感染的成年人进行研究，他们每个人的血清中都含有针对B族链球菌III型荚膜多糖的抗体。相比之下，10名已从因B族链球菌III型引起的菌血症、败血症和/或脑膜炎中康复的婴儿血清中没有抗体。
